التفاصيل البيبلوغرافية
| العنوان: |
Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders. |
| المؤلفون: |
Hadar, Ravit, Edemann-Callesen, Henriette, Reinel, Claudia, Wieske, Franziska, Voget, Mareike, Popova, Elena, Sohr, Reinhard, Avchalumov, Yosef, Priller, Josef, van Riesen, Christoph, Puls, Imke, Bader, Michael, Winter, Christine |
| المصدر: |
Scientific Reports; 12/16/2016, p39145, 1p |
| مستخلص: |
The dopamine transporter (DAT) plays a pivotal role in maintaining optimal dopamine signaling. DAT-overactivity has been linked to various neuropsychiatric disorders yet so far the direct pathological consequences of it has not been fully assessed. We here generated a transgenic rat model that via pronuclear microinjection overexpresses the DAT gene. Our results demonstrate that DAT-overexpression induces multiple neurobiological effects that exceeded the expected alterations in the corticostriatal dopamine system. Furthermore, transgenic rats specifically exhibited behavioral and pharmaco-therapeutic profiles phenotypic of repetitive disorders. Together our findings suggest that the DAT rat model will constitute a valuable tool for further investigations into the pathological influence of DAT overexpression on neural systems relevant to neuropsychiatric disorders. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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