دورية أكاديمية
Potential effects of high plasma to red blood cell ratio transfusion in pediatric trauma.
| العنوان: | Potential effects of high plasma to red blood cell ratio transfusion in pediatric trauma. |
|---|---|
| المؤلفون: | Hwu, Ruth S., Keller, Martin S., Spinella, Philip C., Baker, David, Tao, Yu, Leonard, Julie C. |
| المصدر: | Trauma; Jan2017, Vol. 19 Issue 1, p21-27, 7p, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: | WOUND care, RED blood cell transfusion, HEMORRHAGE, HOSPITAL emergency services, EVALUATION of medical care, RETROSPECTIVE studies, HOSPITAL mortality, CHILDREN |
| مستخلص: | Objective High ratio of plasma to red blood cells during massive transfusion is associated with improved survival of traumatic injuries in adults, but this has not been demonstrated in children. Our objective was to compare the outcome of children who received high (≥1:2) versus low (<1:2) plasma: red blood cells (P:R) ratios at 24 h from injury. Methods We conducted a retrospective chart review of children <18 years of age who presented to the emergency department over a 7-year period and received massive transfusion (≥40 ml/kg red blood cells or ≥80 ml/kg total blood products in 24 h). Our primary outcome of interest was in-hospital mortality. Results We identified 38 children who received massive transfusion. There was no significant difference in in-hospital mortality (45.8% vs. 64.3%) between the high (n = 24, median ratio 1:1.1) and low P:R ratio (n = 14, median 1:3.2) groups. In subset analyses, there was reduced mortality for high P:R patients with BIG score ≥24 (69.2% vs. 100%) and those taken to the operating room within 6 h of arrival (21.4% vs. 60.0%), respectively (p < 0.05). There was a trend for improved survival in high P:R patients without severe traumatic brain injury (TBI) (0% vs. 40.0%). Conclusions This study suggests that high P:R transfusion may improve in-hospital survival of injured children at high risk of mortality and in children without severe TBI, supporting the need for large, multi-center studies. [ABSTRACT FROM AUTHOR] |
| Copyright of Trauma is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder كن أول من يترك تعليقا!