التفاصيل البيبلوغرافية
| العنوان: |
Chinese medicine for idiopathic Parkinson's disease: A meta analysis of randomized controlled trials. |
| المؤلفون: |
Wei, Wei, Chen, Hai-yong, Fan, Wen, Ye, Shui-fen, Xu, Yi-hui, Cai, Jing |
| المصدر: |
Chinese Journal of Integrative Medicine; Jan2017, Vol. 23 Issue 1, p55-61, 7p |
| مصطلحات موضوعية: |
DRUG therapy for Parkinson's disease, ANTIPARKINSONIAN agents, CONFIDENCE intervals, INFORMATION storage & retrieval systems, MEDICAL databases, CHINESE medicine, MEDLINE, META-analysis, ONLINE information services, QUESTIONNAIRES, SYSTEMATIC reviews, INTEGRATIVE medicine, RANDOMIZED controlled trials, DESCRIPTIVE statistics |
| مستخلص: |
Objective: To evaluate the efficacy of Chinese medicine (CM) adjunct to conventional medications for idiopathic Parkinson's disease (PD). Methods: Electronic English and Chinese databases including PubMed, Cochrane Library, Web of Science, Chinese Medical Current Contents, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Med Database, and Traditional Chinese Medical Database System were used for key words searching in a highly sensitive search strategy. The extracted data was analyzed by the Review Manager 5.0. Results: Twelve trials involving 869 participants were included in the meta-analysis. Unified PD Rating Scale (UPDRS) I, II, III, IV scores and UPDRS V-IV total scores were used to be the primary outcomes, Parkinson Disease Question-39 (PDQ-39) and Scores of Chinese Medical Symptoms were the secondary outcomes. CM adjunct therapy had greater improvement in UPDRS I [2 trials; standardized mean difference (SMD)-0.40, 95% confidence interval (CI)-0.71 to-0.09; Z=2.49 ( P=0.01)], II [5 trials; SMD-0.47, 95% CI-0.69 to-0.25; Z=4.20 ( P<0.01)], III [5 trials; SMD-0.35, 95% CI-0.57 to-0.13; Z=3.16 ( P=0.002)], IV scores [3 trials; SMD-0.32, 95% CI-0.60 to-0.03; Z=2.17 ( P=0.03)], UPDRS I-IV total scores [7 trials; SMD-0.36, 95%CI-0.53 to-0.20; Z=4.24 ( P<0.05)]. PDQ-39 and Chinese medical symptoms compared to the conventional medication only. Conclusion: CM adjunct therapy has potential therapeutic benefits by decreasing UPDRS scores and reducing adverse effect. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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