دورية أكاديمية
Change in flash visual evoked potentials in New Zealand albino rabbits after sub-tenon’s anesthesia.
| العنوان: | Change in flash visual evoked potentials in New Zealand albino rabbits after sub-tenon’s anesthesia. |
|---|---|
| المؤلفون: | Wu, Xiaofei, Jhanji, Vishal, Chen, Haoyu, Lin, Hongjie, Zhang, Guihua, Brelen, Marten, Chen, Weiqi |
| المصدر: | Cutaneous & Ocular Toxicology; Jun2017, Vol. 36 Issue 2, p118-124, 7p |
| مصطلحات موضوعية: | ANESTHESIA, BLINDNESS in animals, RABBIT physiology, VETERINARY ophthalmology, LABORATORY rabbits |
| مستخلص: | Context: The occurrence of amaurosis during ophthalmic anesthesia is well known. The reason for this manifestation has not been studied. Purpose: To investigate the effect of sub-tenon’s anesthesia on visual conduction in rabbit eyes. Methods: Fifteen right eyes of 15 New Zealand albino rabbits were included. 2% lidocaine hydrochloride and 0.75% bupivacaine hydrochloride (1 ml, 1:1 mixture) was injected in the sub-tenon’s space of 8 eyes while the control group (n = 7) was injected with 1 ml physiological saline. Flash visual evoked potentials (FVEP) were performed with Roland reti-scan system before and, 5 min, 15 min, and 5 days after injection. The natural pupillary diameter and minimal pupillary diameter with light reflex were recorded. Results: In the anesthesia group, N1 latency, P1 latency, and P1 amplitude were 17.13 ± 1.13 ms, 28.25 ± 1.83 ms, 13.45 ± 4.36 μv respectively before injection; 21.75 ± 3.06 ms, 29.63 ± 2.67 ms, 7.24 ± 4.64 μv at 5 min after injection; 22.25 ± 1.39 ms, 29.50 ± 2.51 ms, 7.54 ± 4.47 μv at 15 min after injection, and, 17.75 ± 0.71 ms, 28.13 ± 2.42 ms, 13.17 ± 4.08 μv 5 days after injection. When compared with baseline, N1 latency at 5 min and 15 min after injection showed prolongation (p = 0.019 andp = 0.001, respectively). Likewise, P1 amplitude decreased at 5 min and 15 min after injection (p < 0.001,p < 0.001, respectively). Both N1 latency and P1 amplitude recovered 5 days after the injection. Pupillary light reflex (PLR) constriction amplitude was 35.42% and 0.00% before and at 5 min after injection (p = 0.012). After 5 days it recovered to 33.33%. The FVEP and PLR constriction amplitude did not change significantly after injection in the control group. Discussion: Sub-tenon’s anesthesia was associated with changes in the FVEP and pupullary light reflex in rabbit eyes in our study. Conclusions: The data from this study suggested that sub-tenon’s anesthesia could reversibly block visual conduction in rabbit’s eyes. [ABSTRACT FROM AUTHOR] |
| Copyright of Cutaneous & Ocular Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
PDF full text from Publisher كن أول من يترك تعليقا!