التفاصيل البيبلوغرافية
| العنوان: |
Reversal learning reveals cognitive deficits and altered prediction error encoding in the ventral striatum in Huntington's disease. |
| المؤلفون: |
Nickchen, Katharina, Boehme, Rebecca, Mar Amador, Maria, Hälbig, Thomas, Dehnicke, Katharina, Panneck, Patricia, Behr, Joachim, Prass, Konstantin, Heinz, Andreas, Deserno, Lorenz, Schlagenhauf, Florian, Priller, Josef, Del Mar Amador, Maria, Hälbig, Thomas D |
| المصدر: |
Brain Imaging & Behavior; Dec2017, Vol. 11 Issue 6, p1862-1872, 11p |
| مستخلص: |
Huntington's disease (HD) is an autosomal dominant neurodegenerative condition characterized by a triad of movement disorder, neuropsychiatric symptoms and cognitive deficits. The striatum is particularly vulnerable to the effects of mutant huntingtin, and cell loss can already be found in presymptomatic stages. Since the striatum is well known for its role in reinforcement learning, we hypothesized to find altered behavioral and neural responses in HD patients in a probabilistic reinforcement learning task performed during functional magnetic resonance imaging. We studied 24 HD patients without central nervous system (CNS)-active medication and 25 healthy controls. Twenty HD patients and 24 healthy controls were able to complete the task. Computational modeling was used to calculate prediction error values and estimate individual parameters. We observed that gray matter density and prediction error signals during the learning task were related to disease stage. HD patients in advanced disease stages appear to use a less complex strategy in the reversal learning task. In contrast, HD patients in early disease stages show intact encoding of learning signals in the degenerating left ventral striatum. This effect appears to be lost with disease progression. [ABSTRACT FROM AUTHOR] |
|
Copyright of Brain Imaging & Behavior is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder