التفاصيل البيبلوغرافية
| العنوان: |
Gender affects prognosis of methicillin-resistant Staphylococcus aureus bacteremia differently depending on the severity of underlying disease. |
| المؤلفون: |
the Korea INfectious Diseases (KIND) study group, Kang, Chang Kyung, Park, Youngmi, Song, Kyoung-Ho, Kim, Eu Suk, Kim, Hong Bin, Kim, Chung-Jong, Kim, Yeon-Sook, Kwak, Yee Gyung, Jung, Sook-In, Park, Kyung-Hwa, Park, Wan Beom, Kim, Nam Joong, Kim, Young Keun, Jang, Hee-Chang, Lee, Shinwon, Jeon, Jae Hyun, Kwon, Ki Tae |
| المصدر: |
European Journal of Clinical Microbiology & Infectious Diseases; Jun2018, Vol. 37 Issue 6, p1119-1123, 5p |
| مصطلحات موضوعية: |
GENDER, BACTEREMIA, MORTALITY, STAPHYLOCOCCUS aureus |
| مصطلحات جغرافية: |
KOREA |
| مستخلص: |
We aimed to elucidate the potential impact of gender on prognosis of Staphylococcus aureus bacteremia (SAB). We analyzed SAB cases prospectively collected over an 8-year period at 11 hospitals in Korea. SAB-related mortality was pre-defined as a death within 30 days from the onset of SAB without other apparent cause of death. The effect of gender on SAB-related mortality was examined in the entire cohort and in subgroups stratified according to methicillin resistance and Charlson’s comorbidity-weighted index (CCWI) score. Those factors independently associated to SAB-related mortality were explored. Among 1974 eligible cases, SAB-related mortality rates in male and female were 21.2% (259/1224) and 21.9% (164/750), respectively (P = 0.786). The SAB-related mortality rate was independently higher in male than that in female in CCWI score ≤ 3 methicillin-resistant SAB (MRSAB) group (15.9 vs. 6.2%; aOR 3.65, 95% CI 1.46-9.13; P = 0.006) while the association tended to be inverse when CCWI score rises. Interaction between CCWI score and gender to MRSAB-related mortality was significant in multivariate analysis (aOR 0.85, 95% CI 0.74-0.96; P = 0.011). There was no significant interaction between gender and CCWI in entire SAB or methicillin-susceptible SAB cohorts. Gender may affect clinical outcomes of MRSAB differently depending on the severity of underlying disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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