التفاصيل البيبلوغرافية
| العنوان: |
IFNβ inhibits the development of allergen tolerance and is conducive to the development of asthma on subsequent allergen exposure. |
| المؤلفون: |
Fear, Vanessa S., Poh, Wee Peng, Gorman, Shelley, Waithman, Jason C., Fear, Mark W. |
| المصدر: |
Immunology & Cell Biology; Sep2018, Vol. 96 Issue 8, p841-851, 11p |
| مصطلحات موضوعية: |
IMMUNE response, IMMUNOLOGIC diseases, ALLERGENS, T cells, CYTOKINES |
| مستخلص: |
Abstract: Asthma is a chronic disease affecting up to 10% of the Australian population for which medical treatment is solely aimed at relief of symptoms rather than prevention of disease. Evidence from animal and human studies demonstrates a strong link between viral respiratory infections, atopy and the development of asthma. Type I IFNs include IFNα and IFNβ, with subtype expression tailored toward the specific viral infection. We hypothesized that exposure to type I IFNs and allergen may interfere with the healthy response to innocuous airway antigen exposure. In this study, we use an ovalbumin (OVA)‐induced BALB/c model of experimental allergic airways disease, where pre‐exposure of the airways to OVA is protective against allergen sensitization, leading to allergen tolerance. We investigated airways pre‐exposure with OVA and type I IFNs on development of allergic airways disease. We demonstrate restoration of allergic airways disease on pre‐exposure with allergen and IFNβ, and not IFNα. Dysfunction in tolerance led to changes in dendritic cell antigen capture/traffic, T‐cell and B‐cell responses. Furthermore, exposure to IFNβ with ongoing allergen exposure led to the development of hallmark asthma features, including OVA‐specific IgE and airways eosinophilia. Data indicate a role for IFNβ in linking viral infection and allergy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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