دورية أكاديمية
Genome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle.
العنوان: | Genome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle. |
---|---|
المؤلفون: | May, Katharina, Scheper, Carsten, Brügemann, Kerstin, Yin, Tong, Strube, Christina, Korkuć, Paula, Brockmann, Gudrun A., König, Sven |
المصدر: | BMC Genomics; 4/8/2019, Vol. 20 Issue 1, pN.PAG-N.PAG, 1p, 3 Charts, 4 Graphs |
مصطلحات موضوعية: | CATTLE genetics, ENDOPARASITES, LIVER flukes, DICTYOCAULUS viviparous, MILK yield |
مستخلص: | Background: Gastrointestinal nematodes (GIN), liver flukes (Fasciola hepatica) and bovine lungworms (Dictyocaulus viviparus) are the most important parasitic agents in pastured dairy cattle. Endoparasite infections are associated with reduced milk production and detrimental impacts on female fertility, contributing to economic losses in affected farms. In quantitative-genetic studies, the heritabilities for GIN and F. hepatica were moderate, encouraging studies on genomic scales. Genome-wide association studies (GWAS) based on dense single nucleotide polymorphism (SNP) marker panels allow exploration of the underlying genomic architecture of complex disease traits. The current GWAS combined the identification of potential candidate genes with pathway analyses to obtain deeper insights into bovine immune response and the mechanisms of resistance against endoparasite infections. Results: A 2-step approach was applied to infer genome-wide associations in an endangered dual-purpose cattle subpopulation [Deutsches Schwarzbuntes Niederungsrind (DSN)] with a limited number of phenotypic records. First, endoparasite traits from a population of 1166 Black and White dairy cows [including Holstein Friesian (HF) and DSN] naturally infected with GIN, F. hepatica and D. viviparus were precorrected for fixed effects using linear mixed models. Afterwards, the precorrected phenotypes were the dependent traits (rFEC-GIN, rFEC-FH, and rFLC-DV) in GWAS based on 423,654 SNPs from 148 DSN cows. We identified 44 SNPs above the genome-wide significance threshold (p |
Copyright of BMC Genomics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
قاعدة البيانات: | Complementary Index |
كن أول من يترك تعليقا!