دورية أكاديمية
Boundary mode lubrication of articular cartilage with a biomimetic diblock copolymer.
| العنوان: | Boundary mode lubrication of articular cartilage with a biomimetic diblock copolymer. |
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| المؤلفون: | Zhexun Sun, Feeney, Elizabeth, Ya Guan, Cook, Sierra G., Gourdon, Delphine, Bonassar, Lawrence J., Putnam, David |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America; 6/18/2019, Vol. 116 Issue 25, p12437-12441, 5p |
| مصطلحات موضوعية: | BOUNDARY lubrication, ARTICULAR cartilage, DIBLOCK copolymers, BLOCK copolymers, LUBRICATION & lubricants, CARTILAGE |
| مستخلص: | We report the design of a diblock copolymer with architecture and function inspired by the lubricating glycoprotein lubricin. This diblock copolymer, synthesized by sequential reversible addition-fragmentation chain-transfer polymerization, consists of a cationic cartilage-binding domain and a brush-lubricating domain. It reduces the coefficient of friction of articular cartilage under boundary mode conditions (0.088 ± 0.039) to a level equivalent to that provided by lubricin (0.093 ± 0.011). Additionally, both the EC50 (0.404 mg/mL) and cartilage-binding time constant (7.19 min) of the polymer are comparable to purified human and recombinant lubricin. Like lubricin, the tribological properties of this polymer are dependent on molecular architecture. When the same monomer composition was evaluated either as an AB diblock copolymer or as a random copolymer, the diblock effectively lubricated cartilage under boundary mode conditions whereas the random copolymer did not. Additionally, the individual polymer blocks did not lubricate independently, and lubrication could be competitively inhibited with an excess of binding domain. This diblock copolymer is an example of a synthetic polymer with lubrication properties equal to lubricin under boundary mode conditions, suggesting its potential utility as a therapy for joint pathologies like osteoarthritis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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