دورية أكاديمية
Human papilloma and other DNA virus infections of the cervix: A population based comparative study among tribal and general population in India.
| العنوان: | Human papilloma and other DNA virus infections of the cervix: A population based comparative study among tribal and general population in India. |
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| المؤلفون: | Ghosh, Supriti, Shetty, Ranjitha S., Pattanshetty, Sanjay M., Mallya, Sneha D., Pandey, Deeksha, Kabekkodu, Shama Prasada, Kamath, Veena G., Prabhu, Navya, D’souza, Joslin, Satyamoorthy, Kapaettu |
| المصدر: | PLoS ONE; 6/27/2019, Vol. 14 Issue 6, p1-16, 16p |
| مصطلحات موضوعية: | PAPILLOMAVIRUSES, DNA virus diseases, PAPILLOMAVIRUS diseases, VIRUS diseases, PAPILLOMA, CERVICAL intraepithelial neoplasia, POLYMERASE chain reaction |
| مصطلحات جغرافية: | INDIA, ASIA, KARNATAKA (India) |
| مستخلص: | Background: Despite being preventable, cervical cancer remains a major health concern among women. Persistent Human Papillomavirus (HPV) and other viral co-infections may influence cervical dysplasia. We determined and compared the prevalence and risk factors of cervical viral infections among the tribal and general population of southern coastal Karnataka, India. Methods: A population-based cross-sectional survey was conducted among 1140 and 1100 women from tribal and general population, respectively. Cervical infections with HPV, Epstein-Barr Virus (EBV), Cytomegalovirus (CMV) and Herpes-Simplex Virus (HSV) were examined using polymerase chain reactions (PCR) and DNA sequencing. Results: HPV prevalence was higher among tribal women (40.6%) than general population (14.3%) while the prevalence of EBV (55.1%) and CMV (49.4%) were lower among tribal women than general population (74.3% and 77.5%, respectively). HSV infection was observed in tribal women only (1.8%). Among HR-HPV strains, HPV-18 was predominant among tribal population (28.3%) while, HPV-16 was predominant among the general population (9.1%). Infections were associated with age, educational status, unemployment and personal hygiene of tribal women. Phylogenetic analysis revealed that HPV-16 variants of tribal participants were closely related to non-European sublineages indicating greater risk of HPV persistence and carcinogenesis. Conclusion: The study provides a comparative estimate for DNA virus infections of the cervix among women from general as well as tribal population in this region and also reveals a different type-specific pattern of viral infection. Further research is required to delineate the role of specific interactions between multiple virus infections and their role in carcinogenesis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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