دورية أكاديمية
PRODUCTION AND CHARACTERIZATION OF SELF EMULSIFYING TABLET OF DEXAMETHASONE.
| العنوان: | PRODUCTION AND CHARACTERIZATION OF SELF EMULSIFYING TABLET OF DEXAMETHASONE. |
|---|---|
| المؤلفون: | DASTIDAR, DEBABRATA GHOSH, GHOSH, SOUVIK, SENGUPTA, ABHIJIT, GHOSH, DIPANJAN, DAS, DIBYA, DUTTA, GOURANGA, GUHA, NILAYAN |
| المصدر: | International Journal of Pharmaceutical Research (09752366); Oct-Dec2019, Vol. 11 Issue 4, p197-208, 12p |
| مصطلحات موضوعية: | DEXAMETHASONE, ADRENOCORTICAL hormones, STEROID hormones, PROPYLENE glycols, CASTOR oil, MICROEMULSIONS |
| مستخلص: | Dexamethasone is clinically very important adrenocortical steroid. But erratic oral absorption leading to irregular bioavailability, is the main problems to its clinical use. In this study a self emulsifying tablet of dexamethasone has been developed. Castor oil, Tween® 80 and Propylene glycol were used as oil vehicle, surfactant and cosurfactant. Formulation optimization was done using 9 run Randomized Quadratic D-Optimal Mixture Design. The optimum composition of liquid SEDDS was found out to be 14% (w/w) castor oil, 43% (w/w) Tween® 80 and 43% (w/w) propylene glycol. 1mg dexamethasone was dissolved in 37mg of this mixture. Upon addition in water it produced Grade I type microemulsion with 107.4nm droplet diameter and -18.97mV -potential. The granules prepared with this liquid SEDDS had excellent flow properties. Upon compression it formed tablet with good hardness (3.3 kg/cm2) and low friability (0.48%). Upon addition in water, it disintegrated within 10min and formed colloidal dispersion of 144nm diameter and -15.1mV -potential. DSC results confirmed that dexamethasone was in amorphous state in tablet. This may have increased the aqueous solubility of dexamethasone leading to ~46% burst release of drug in dissolution medium within 5min. Thereafter ~21% drug was released during 90minute at a constant rate of 0.239±0.012% per minute (K |
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| قاعدة البيانات: | Complementary Index |
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