التفاصيل البيبلوغرافية
| العنوان: |
Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data. |
| المؤلفون: |
Pulley, Jill M., Rhoads, Jillian P., Jerome, Rebecca N., Challa, Anup P., Erreger, Kevin B., Joly, Meghan M., Lavieri, Robert R., Perry, Kelly E., Zaleski, Nicole M., Shirey-Rice, Jana K., Aronoff, David M. |
| المصدر: |
Annual Review of Pharmacology & Toxicology; Jan2020, Vol. 60, p333-352, 16p |
| مصطلحات موضوعية: |
DRUG toxicity, PATIENT safety, DRUG development, EVIDENCE-based medicine, DECISION making in clinical medicine, GENOMICS, TREATMENT effectiveness, INDIVIDUALIZED medicine, DATA analytics |
| مستخلص: |
The promise of drug repurposing is to accelerate the translation of knowledge to treatment of human disease, bypassing common challenges associated with drug development to be more time- and cost-efficient. Repurposing has an increased chance of success due to the previous validation of drug safety and allows for the incorporation of omics. Hypothesis-generating omics processes inform drug repurposing decision-making methods on drug efficacy and toxicity. This review summarizes drug repurposing strategies and methodologies in the context of the following omics fields: genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, phenomics, pregomics, and personomics. While each omics field has specific strengths and limitations, incorporating omics into the drug repurposing landscape is integral to its success. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
