التفاصيل البيبلوغرافية
| العنوان: |
Influence of a Combined Gluten-Free and Casein-Free Diet on Behavior Disorders in Children and Adolescents Diagnosed with Autism Spectrum Disorder: A 12-Month Follow-Up Clinical Trial. |
| المؤلفون: |
González-Domenech, Pablo José, Díaz Atienza, Francisco, García Pablos, Carlos, Fernández Soto, María Luisa, Martínez-Ortega, José María, Gutiérrez-Rojas, Luis |
| المصدر: |
Journal of Autism & Developmental Disorders; Mar2020, Vol. 50 Issue 3, p935-948, 14p, 1 Diagram, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
AUTISM, BEHAVIOR disorders in children, CASEINS, CROSSOVER trials, DIET, DIET in disease, DIET therapy, FOOD habits, GLUTEN, GLUTEN-free diet, HEALTH behavior, LONGITUDINAL method, PEPTIDES, QUESTIONNAIRES, STATISTICAL sampling, RANDOMIZED controlled trials, TREATMENT effectiveness, PRE-tests & post-tests |
| مستخلص: |
The use of alternative interventions, such as gluten-free and casein-free (GFCF) diets, is frequent due to limited therapies for Autism Spectrum Disorder (ASD). Our aims were to determine the influence of a GFCF diet on behavior disorders in children and adolescents diagnosed with ASD and the potential association with urinary beta-casomorphin concentrations. Thirty-seven patients were recruited for this crossover trial. Each patient consumed a normal diet (including gluten and casein) for 6 months and a GFCF diet for another 6 months. The order of the intervention (beginning with normal diet or with GFCF diet) was assigned randomly. Patients were evaluated at three time-points (at the beginning of the study, after normal diet and after GFCF diet). Questionnaires regarding behavior and autism and dietary adherence were completed and urinary beta-casomorphin concentrations were determined at each time-point. No significant behavioral changes and no association with urinary beta-casomorphin concentrations were found after GFCF diet. A 6-month GFCF diet do not induce significant changes in behavioral symptoms of autism and urinary beta-casomorphin concentrations. Further studies with a long follow-up period similar to ours and including placebo and blinding elements are needed to identify better those respondents to GFCF diets. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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