دورية أكاديمية
Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects.
العنوان: | Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects. |
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المؤلفون: | Woo Yul Lee, EunSil Oh, Mengqi Cui, Choon Ok Kim, Yeji Lim, Hunam Kim, Hyeonsoo Park, Sukyong Yoon, Min Soo Park, Taegon Hong |
المصدر: | Translational & Clinical Pharmacology; Mar2020, Vol. 28 Issue 1, p55-65, 11p |
مصطلحات موضوعية: | CLARITHROMYCIN, AMOXICILLIN, PROTON pump inhibitors, DRUG interactions, GASTRIC diseases, HELICOBACTER pylori |
مستخلص: | YH4808 is a novel potassium-competitive acid blocker that was developed as a therapeutic agent for gastric acid-related diseases; it may replace proton pump inhibitors, which are widely used in combination with amoxicillin and clarithromycin for Helicobacter pylori eradication. We compared the pharmacokinetic (PK) profiles and safety of amoxicillin, clarithromycin, and YH4808 used as monotherapies or in combination for evaluating potential drug interactions. An open-label, randomized, single-dose, Latin-square (4 x 4) crossover study was conducted in 32 healthy Korean volunteers. Subjects were randomly assigned to one of the 4 treatment sequences that consisted of 4 periods separated by 21-day washout intervals. PK parameters of YH4808, amoxicillin and clarithromycin administered in combination were compared with those of the respective monotherapies. The geometric mean ratios of the maximum concentration (C |
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قاعدة البيانات: | Complementary Index |
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