دورية أكاديمية
An Amide Analog of (−)‐Epigallocatechin Gallate Shows Preferential Cytotoxicity toward Triple‐Negative Breast Cancer Cells.
| العنوان: | An Amide Analog of (−)‐Epigallocatechin Gallate Shows Preferential Cytotoxicity toward Triple‐Negative Breast Cancer Cells. |
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| المؤلفون: | Lee, Tae Gum, Kim, Yulim, Jung, Woong, Kim, Mi Kyoung, Chong, Youhoon |
| المصدر: | Bulletin of the Korean Chemical Society; May2020, Vol. 41 Issue 5, p496-497, 2p |
| مصطلحات موضوعية: | EPIGALLOCATECHIN gallate, TRIPLE-negative breast cancer, PROGESTERONE receptors, CANCER cells, EPIDERMAL growth factor receptors |
| مستخلص: | An Amide Analog of (-)-Epigallocatechin Gallate Shows Preferential Cytotoxicity toward Triple-Negative Breast Cancer Cells Keywords: (-)-Epigallocatechin gallate; Amide; Cytotoxicity; Triple-negative breast cancer EN (-)-Epigallocatechin gallate Amide Cytotoxicity Triple-negative breast cancer 496 497 2 05/26/20 20200501 NES 200501 An ester to amide modification increases anticancer activity of EGCG to MDA-MB-231 cells GLO:1CJF/01may20:bkcs12007-toc-0001.jpg PHOTO (COLOR): . gl MDA-MB-231 is a highly aggressive, invasive and poorly differentiated triple-negative breast cancer (TNBC) cell line as it lacks estrogen receptor and progesterone receptor expression, as well as HER2 (human epidermal growth factor receptor 2) amplification.[[1]] Similar to other invasive cancers, there are only limited treatment options for TNBC and, as a result, there is an urgent need to discover cytotoxic agents against the MDA-MB-231 cells. GLO:1CJF/01may20:bkcs12007-fig-0002.jpg PHOTO (COLOR): Comparison of anticancer effects of EGCG (1) and EGCG-amide (3) against (a) MCF-7 and (b) MDA-MB-231 cells. gl Considering the minimal structural difference between EGCG ( B 1 b ) and EGCG-amide ( B 3 b ) resulting from the isosteric replacement of an ester ( B 1 b ) with an amide ( B 3 b ) functionality, the peculiar cytotoxicity profile of the EGCG-amide ( B 3 b ) against MDA-MB-231 draws special attention. [Extracted from the article] |
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| قاعدة البيانات: | Complementary Index |
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