التفاصيل البيبلوغرافية
| العنوان: |
Omega-3 fatty acid supplementation in pregnancy-baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial. |
| المؤلفون: |
Simmonds, LA, Sullivan, TR, Skubisz, M, Middleton, PF, Best, KP, Yelland, LN, Quinlivan, J, Zhou, SJ, Liu, G, McPhee, AJ, Gibson, RA, Makrides, M, Simmonds, L A, Sullivan, T R, Middleton, P F, Best, K P, Yelland, L N, Zhou, S J, McPhee, A J, Gibson, R A |
| المصدر: |
BJOG: An International Journal of Obstetrics & Gynaecology; Jul2020, Vol. 127 Issue 8, p975-981, 7p, 1 Diagram, 2 Graphs |
| مصطلحات موضوعية: |
OMEGA-3 fatty acids, PREMATURE labor, UNSATURATED fatty acids, PREGNANCY, BLOOD lipids, THERAPEUTIC use of omega-3 fatty acids, RESEARCH, PREMATURE infants, RESEARCH methodology, GESTATIONAL age, EVALUATION research, MEDICAL cooperation, DIETARY supplements, PREGNANCY outcomes, COMPARATIVE studies, RESEARCH funding, LONGITUDINAL method |
| مصطلحات جغرافية: |
AUSTRALIA |
| مستخلص: |
Objective: To identify a polyunsaturated fatty acid (PUFA) biomarker able to detect which women with singleton pregnancies are most likely to benefit from omega-3 supplementation to reduce their risk of early preterm birth.Design: Exploratory analysis of a randomised controlled trial.Setting: Six Australian hospitals.Population: Women with a singleton pregnancy enrolled in the ORIP trial.Methods: Using maternal capillary whole blood collected ~14 weeks' gestation, the fatty acids in total blood lipids were quantified using gas chromatography. Interaction tests examined whether baseline PUFA status modified the effect of omega-3 supplementation on birth outcomes.Main Outcome Measure: Early preterm birth (<34 weeks' gestation).Results: A low total omega-3 PUFA status in early pregnancy was associated with a higher risk of early preterm birth. Among women with a total omega-3 status ≤4.1% of total fatty acids, omega-3 supplementation substantially reduced the risk of early preterm birth compared with control (0.73 versus 3.16%; relative risk = 0.23, 95% confidence interval [CI] 0.07-0.79). Conversely, women with higher total omega-3 status in early pregnancy were at lower risk of early preterm birth. Supplementing women with a baseline status above 4.9% increased early preterm birth (2.20 versus 0.97%; relative risk = 2.27, 95% CI 1.13-4.58).Conclusions: Women with singleton pregnancies and low total omega-3 PUFA status early in pregnancy have an increased risk of early preterm birth and are most likely to benefit from omega-3 supplementation to reduce this risk. Women with higher total omega-3 status are at lower risk and additional omega-3 supplementation may increase their risk.Tweetable Abstract: Low total omega-3 fat status helps identify which women benefit from extra omega-3 to reduce early prematurity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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