التفاصيل البيبلوغرافية
| العنوان: |
Acute and sub-acute oral toxicity and phytochemical profile of Croton menyharthii plant from Tana River County Kenya. |
| المؤلفون: |
Kagunya, Emma Wanjiku, Kaingu, Catherine Kaluwa, Mbaria, James Mucunu |
| المصدر: |
Discovery Phytomedicine; 2020, Vol. 7 Issue 3, p118-127, 10p |
| مصطلحات موضوعية: |
CROTON (Genus), PLANT extracts, TREATMENT of dysmenorrhea, ABORTION prevention, PHYTOCHEMICALS |
| مستخلص: |
Croton menyharthii root bark is used to manage female reproductive ailments in Tana River County, Kenya. The plant treats dysmenorrhea, prevents abortion, stops post-partum hemorrhage and is also a contraceptive. Toxicological and phytochemical profile of the plant is still unknown. Preliminary phytochemical screening of Dichloromethane-Methanol and aqueous Croton menyharthii root bark extracts was carried out as per method used by Kisianan et al., 2019. Acute oral toxicity study was conducted using female rats by using OECD 423 guidelines whereas the sub-acute toxicity study was carried out using OECD 407 guidelines. General behavior, adverse effects and mortality were keenly observed throughout the experimental period. Food intake, water intake, body weight, organ weight, hematological and biochemical parameters were evaluated. Alkaloids, saponins, phenols, cardiac glycosides and tannins were present in both organic and aqueous extract. Both extracts had acute oral toxicity greater than 2000 mg/kg. In the sub-acute toxicity study, there was a significant dose-dependent decrease in the levels of total protein in rats treated with 200 (P<0.006), 400 (P<0.00) and 800 mg/kg (P< 0.00) aqueous extract relative to the control. None of the extracts caused a significant effect on haematological parameters. Long term administration of Croton menyharthii root bark extract is associated with significant alterations in renal physiology. Given the finding, we recommend the judicious use of the root bark extracts of Croton menyharthii particularly when long term use is being considered. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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