التفاصيل البيبلوغرافية
| العنوان: |
Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats. |
| المؤلفون: |
Chuang, Hsiao-Chi, Chen, Hsin-Chang, Chai, Pei-Jui, Liao, Ho-Tang, Wu, Chang-Fu, Chen, Chia-Ling, Jhan, Ming-Kai, Hsieh, Hui-I, Wu, Kuen-Yuh, Chen, Ta-Fu, Cheng, Tsun-Jen |
| المصدر: |
Particle & Fibre Toxicology; 11/26/2020, Vol. 17 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
NEUROLOGICAL disorders, OLFACTORY bulb, PARTICULATE matter, HIPPOCAMPUS (Brain), HYPERTENSION |
| مستخلص: |
Background: Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats. Results: SH rats were exposed to S-, K-, Si-, and Fe-dominated PM2.5 at 8.6 ± 2.5 and 10.8 ± 3.8 μg/m3 for 3 and 6 months, respectively. We observed no significant alterations in the escape latency, distance moved, mean area crossing, mean time spent, or mean swimming velocity after PM2.5 exposure. Notably, levels of MDA had significantly increased in the olfactory bulb, hippocampus, and cortex after 6 months of PM2.5 exposure (p < 0.05). We observed that 3 months of exposure to PM2.5 caused significantly higher expressions of t-tau and p-tau in the olfactory bulb (p < 0.05) but not in other brain regions. Beclin 1 was overexpressed in the hippocampus with 3 months of PM2.5 exposure, but significantly decreased in the cortex with 6 months exposure to PM2.5. Neuron numbers had decreased with caspase-3 activation in the cerebellum, hippocampus, and cortex after 6 months of PM2.5 exposure. Conclusions: Chronic exposure to low-level PM2.5 could accelerate the development of neurodegenerative pathologies in subjects with hypertension. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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