التفاصيل البيبلوغرافية
| العنوان: |
The effect of warfarin administration on platelet aggregation. |
| المؤلفون: |
M., Chylova, Z., Motovska, A., Fialova, I., Stetkarova, T., Peisker, P., Kalvach |
| المصدر: |
Bratislava Medical Journal / Bratislavské Lekárske Listy; 2021, Vol. 122 Issue 5, p320-324, 5p |
| مصطلحات موضوعية: |
PLATELET aggregation inhibitors, WARFARIN, PLATELET function tests, BLEEDING time (Medical test), ANTICOAGULANTS |
| مستخلص: |
BACKGROUND: The aim of this study was to assess the effect of anticoagulation treatment on platelet aggregation. METHODS: The study group consisted of 24 patients on long-term warfarin therapy without any antiaggregation therapy. Platelet aggregation was measured using Verify Now with arachidonic acid (AA) as an inducer in 23 patients and with light transmission aggregometry (LTA) in 19 patients using four different agonists. All patients had their international normalized ratio (INR) checked regularly. RESULTS: The mean INR value was 2.07 (SD 0.6). The average aggregation measured by VerifyNow was found to be 637.5 (SD 36.6) aspirin reaction units. The values of average aggregability in LTA were 73.3 % (SD 4.5 %), 73.2 % (SD 6 %) and 72.1 % (SD 4.8 %) in case of aggregation induced by AA, ADP, and collagen, respectively. Epinephrine-induced aggregability was 65.3 % (SD 14.7 %). Regression analysis between INR and values of collagen- or epinephrine-induced aggregability (r = 0.654 and 0.575) was found statistically signifi cant (p = 0.004 and 0.016); every increase in INR by 0,1 brings about an increase in collagen- and epinephrine-induced aggregation values by 1.5 and 4, respectively. CONCLUSION: Administration of warfarin does not produce a signifi cant reduction in platelet aggregation. On the contrary, prolonged INR evokes a mild increase in aggregation induced by collagen or epinephrine (Tab. 2, Fig. 3, Ref. 32). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
