دورية أكاديمية
أعرض في EDS

Preserved Versus Preservative-Free Latanoprost for the Treatment of Glaucoma and Ocular Hypertension: A Post Hoc Pooled Analysis.

التفاصيل البيبلوغرافية
العنوان: Preserved Versus Preservative-Free Latanoprost for the Treatment of Glaucoma and Ocular Hypertension: A Post Hoc Pooled Analysis.
المؤلفون: Harasymowycz, Paul, Hutnik, Cindy, Rouland, Jean-François, Negrete, Francisco J. Muñoz, Economou, Mario A., Denis, Philippe, Baudouin, Christophe
المصدر: Advances in Therapy; Jun2021, Vol. 38 Issue 6, p3019-3031, 13p
مصطلحات موضوعية: ANTIHYPERTENSIVE agents, RESEARCH, GLAUCOMA, SYNTHETIC prostaglandins F, INTRAOCULAR pressure, OCULAR hypertension, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, OPHTHALMIC drugs, TREATMENT effectiveness, COMPARATIVE studies
مستخلص: Introduction: To compare the tolerability and efficacy of a preservative-containing latanoprost (PCL) to a preservative-free formulation of latanoprost (PFL) in patients with open-angle glaucoma or ocular hypertension.Methods: A pooled analysis was performed of data from five published studies. The primary outcome was tolerability as evaluated by the severity of hyperemia. The secondary objectives were patient tolerance based on a composite ocular surface disease (OSD) score arising from ocular signs and symptoms, patient and investigator satisfaction, and a comparison of IOP-lowering efficacy.Results: There were three randomized controlled trials and two observational studies included in the analysis. Conjunctival hyperemia improved significantly in 25.6% (388) of patients switched to the PFL group versus 11.7% (117) of patients switched to the PCL group (p < 0.001). PFL was two times superior to PCL in reducing ocular hyperemia (odds ratio = 1.96; p < 0.001). The mean OSD composite score decreased by 32.2% in patients switched to the PFL group and 14.1% in the PCL group (p < 0.001). At 3 months, the mean IOP was similar between groups (p = 0.312).Conclusion: This post hoc pooled analysis confirmed the findings of the individual studies that PFL is as efficacious at reducing IOP as PCL but better tolerated. After switching to PFL, there was twice the improvement in the OSD composite score. PFL was twice as effective at reducing ocular hyperemia and other ocular signs. These findings suggest that PFL has features that may improve patient compliance, thereby potentially improving the IOP-lowering efficacy on a long-term basis. [ABSTRACT FROM AUTHOR]
Copyright of Advances in Therapy is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
قاعدة البيانات: Complementary Index
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا