دورية أكاديمية
Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion.
| العنوان: | Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion. |
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| المؤلفون: | Tang, Lipeng, Li, Tong, Zhang, Bowen, Zhang, Zihao, Sun, Xiaoyi, Zhu, Ying, Feng, Bing, Su, Zuqing, Yang, Laijun, Li, Hongxia, Liu, Huazhen, Chen, Yuchao, Dai, Zhenhua, Zheng, Xirun, Li, Mingxian, Li, Chutian, Zhao, Jie, Qiu, Xinmin, Ye, Shuyan, Liu, Han |
| المصدر: | Frontiers in Pharmacology; 1/26/2022, Vol. 13, p1-10, 10p |
| مصطلحات موضوعية: | NF-kappa B, TUMOR necrosis factors, PSORIASIS, POMEGRANATE |
| مستخلص: | Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate (Punica granatum L.) peel with multiple biological activities, such as antibacterial, antioxidant and anti-tumor effects. However, the potential effect of PUN on psoriasis remains unknown. In this study, we want to investigate the pharmacological effect of PUN on psoriasis by using imiquimod (IMQ)-induced psoriatic mice model in vivo and tumor necrosis factor a (TNF-α) and interleukin-17A (IL-17A)-stimulated HaCaT cells in vitro. Our results showed that PUN can effectively alleviate the severity of psoriasis-like symptoms. Mechanistically, PUN potently suppresses the aberrant upregulation of interleukin-1β (IL-1β) and subsequent IL-1β-mediated inflammatory cascade in keratinocytes by inhibiting the nuclear factor kappa B (NF-κB) activation and cleaved caspase-1 expression in vitro and in vivo. Taken together, our findings indicate that PUN can relieve psoriasis by repressing NF-κB-mediated IL-1β transcription and caspase-1-regulated IL-1β secretion, which provide evidence that PUN might represent a novel and promising candidate for the treatment of psoriasis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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