دورية أكاديمية
The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen.
العنوان: | The voltage-gated K+ channel Kv1.3 modulates platelet motility and α |
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المؤلفون: | Wright, Joy R, Jones, Sarah, Parvathy, Sasikumar, Kaczmarek, Leonard K, Forsythe, Ian, Farndale, Richard W, Gibbins, Jonathan M, Mahaut-Smith, Martyn P |
المصدر: | Platelets; 2022, Vol. 33 Issue 3, p451-461, 11p |
مصطلحات موضوعية: | BLOOD platelets, BLOOD platelet aggregation, PLATELET count, COLLAGEN, MUSCLE injuries, FILOPODIA, TYPE 2 diabetes |
مستخلص: | Kv1.3 is a voltage-gated K+-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution to platelet function is poorly understood. Here we show that Kv1.3-deficient platelets display enhanced ADP-evoked platelet aggregation and secretion, and an increased surface expression of platelet integrin α |
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قاعدة البيانات: | Complementary Index |
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