التفاصيل البيبلوغرافية
| العنوان: |
Pregnancy‐induced brain magnetic resonance imaging changes in women with multiple sclerosis. |
| المؤلفون: |
Uher, Tomas, Kubala Havrdova, Eva, Vodehnalova, Karolina, Krasensky, Jan, Capek, Vaclav, Vaneckova, Manuela, Horakova, Dana |
| المصدر: |
European Journal of Neurology; May2022, Vol. 29 Issue 5, p1446-1456, 11p |
| مصطلحات موضوعية: |
MAGNETIC resonance imaging, MULTIPLE sclerosis, PUERPERIUM, DISABILITIES, DISEASE duration |
| مستخلص: |
Background and purpose: The effect of pregnancy on brain changes and radiological disease activity in women with multiple sclerosis (MS) is not well understood. This study was undertaken to describe the dynamics of lesion activity and brain volume changes during the pregnancy and postpartum periods. Methods: This observational study of 62 women with relapsing–remitting MS included magnetic resonance imaging (221 scans) as well as clinical visits at baseline (<24 and >6 months before pregnancy), prepregnancy (<6 months before pregnancy), postpartum (<3 months after delivery), and follow‐up (>12 and <24 months after delivery) periods. Results: The majority of women had a mild disability and a short disease duration (median = 5.5 years). Eighteen (29.0%) women had a relapse during the year preceding pregnancy onset, nine (14.5%) during pregnancy, and 20 (32.3%) in the year following delivery. Disability status remained unchanged during follow‐up. Women in the postpartum period (n = 62) had higher T2 lesion volume (median = 1.18 ml vs. 0.94 ml), greater annualized T2 lesion volume increase (0.23 ml vs. 0.0 ml), lower brain parenchymal fraction (85.6% vs. 86.4%), and greater annualized brain volume loss (‐1.74% vs. ‐0.16%) compared with the prepregnancy period (all p < 0.001). At 12–24 months after delivery, women (n = 41) had higher T2 lesion volume (1.16 ml vs. 1.0 ml) and lower brain parenchymal fraction (86.0% vs. 86.5%) compared to the prepregnancy period (both p < 0.001). Conclusions: The postpartum period was associated with an increase in T2 lesion volume and accelerated brain volume loss in a considerable proportion of women. This should be considered in treatment decision‐making and designing clinical trials. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder