دورية أكاديمية
Norovirus strains among children aged 0–18 years hospitalized with acute gastroenteritis in Estonia 2015–2016.
| العنوان: | Norovirus strains among children aged 0–18 years hospitalized with acute gastroenteritis in Estonia 2015–2016. |
|---|---|
| المؤلفون: | Kõivumägi, Kadri, Geller, Julia, Toompere, Karolin, Soeorg, Hiie, Kallas, Eveli, Jõgeda, Ene‐Ly, Huik, Kristi, Lutsar, Irja |
| المصدر: | Journal of Medical Virology; Jun2022, Vol. 94 Issue 6, p2632-2639, 8p |
| مصطلحات موضوعية: | GASTROENTERITIS, NOROVIRUSES, RNA polymerases, ROTAVIRUS vaccines, AGE groups, CIRCOVIRUS diseases |
| مصطلحات جغرافية: | ESTONIA |
| مستخلص: | Norovirus (NoV) is the leading cause of acute gastroenteritis (AGE) in many countries that have introduced universal rotavirus mass vaccination. This is the first study to report data on NoV strains in Estonia. We recruited 2249 children aged 0–18 years hospitalized for AGE in Estonian hospitals from February 1, 2015 to August 31, 2016. Norovirus gastroenteritis (NoVGE) was diagnosed in 14.5% (n = 325) cases. Stool sample for RNA extraction and genotyping was available in 86% (n = 280) of NoVGE cases (2015, n = 91; 2016, n = 189). Dominant capsid types detected in 75% (n = 210) samples were, GII.4 (63.8%, n = 134), GII.3 (15.2%, n = 32), GII.17 (6.7%, n = 14), and GII.6 (5.2%, n = 11). Prevailing RNA polymerase types found in 77% (n = 215) samples were GII.P31 (51.1%, n = 110), GII.P21 (17.7%, n = 38), GII.P4 (11.2%, n = 24), and GII.P7 (6.5%, n = 14). Both regions were typeable for 67% (n = 189) of samples. Most prevalent strains were GII.4Sydney_2012[P31] (48.7%, n = 92), GII.3[P21] (15.3%, n = 29), GII.4Sydney_2012[P4] (5.8%, n = 11) and GII.17[P17] (5.8%, n = 11). Simpson's diversity index showed a significant difference between the age groups 1–4 and 5–9 years: D 0.64 (95% confidence interval [CI]: 0.55–0.73) versus 0.83 (95% CI: 0.81–0.86), respectively (p = 0.03). An accurate understanding of NoV strain diversity is important for control and preventive measures, especially in the postrotavirus vaccine era. Highlights: NoVGE is an important cause of hospitalization in children ≤5 years.High genotypic diversity of cocirculating NoV strains in Estonia was seen.With predominance of GII.4 strain a vaccine with broad GII strain coverage is indicated. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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