دورية أكاديمية
Antidiabetic activities and relief of anxiety and stress by seed extract from Mucuna pruriens var. utilis (Wall. ex Wight) Baker ex Burck.
العنوان: | Antidiabetic activities and relief of anxiety and stress by seed extract from Mucuna pruriens var. utilis (Wall. ex Wight) Baker ex Burck. (English) |
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المؤلفون: | Nopparat Buddhakala, Manita Chorum, Chusri Talubmook, Krittiya Thisakorn, Orathai Sarakul |
المصدر: | Journal of Science & Technology MSU; May/Jun2022, Vol. 41 Issue 3, p117-133, 17p |
مصطلحات موضوعية: | STEARIC acid, PALMITIC acid, ANXIETY, PARKINSON'S disease, ETHANOL, HYPOGLYCEMIC agents, ETHYL esters |
مستخلص: | Mucuna pruriens var. utilis (Wall. ex Wight) Baker ex Burck has been used as a traditional medicine for a long time to treat several diseases such as malaria, cancer, diabetes, Parkinson's disease, anxiety disorder and to improve sexual performance. This research investigated phytochemical constituents, anxiety and stress relieving properties, and antidiabetic activities of seed extract from M. pruriens (MPSE) extracted with 95% ethanol. Analysis using GC-MS revealed the presence of 48 chemical compounds with 9 main compounds including 5-Hydroxymethylfurfural, Dodecanamide, N-(2-hydroxyethyl)-, 9,12-Octadecadienoic acid, (Z, Z)-, n-Hexadecanoic acid, endo-Borneol, 9,12-Octadecadienoic acid, ethyl ester, Hexadecanoic acid, ethyl ester, Octadecanoic acid and 9-Octadecenoic acid, and another 39 trace compounds in the extract. Evaluation using light/dark task, hole board and force plate actimeter (FPA) revealed that the number of entries into the chamber, number of rear in dark chamber, time spent in light chamber and the number of entries to the hole board of the 400 mg/kg body weight, MPSE treated mice were significantly (p<0.05) higher than those of the controls, whilst the latency to enter the light chamber was less than that of the controls. In addition, the sleeping time of the MPSE treated mice was significantly (p<0.05) longer than that of the controls. Furthermore, MPSE exhibited an inhibitory effect on α-glucosidase activity with IC |
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قاعدة البيانات: | Complementary Index |
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