التفاصيل البيبلوغرافية
العنوان: |
Seroprevalence and clinical outcomes of SARS-CoV-2 in paediatric patients with rheumatic disease. |
المؤلفون: |
Walters, Heather M, Mian, Zanab, Thomas, Lydia, Cerise, Jane, Eberhard, B Anne, Pagano, Eileen, Gottlieb, Beth S, Steigerwald, Katherine, Hui-Yuen, Joyce S |
المصدر: |
Rheumatology; 2022 Special Issue, Vol. 61, pSI112-SI119, 8p |
مصطلحات موضوعية: |
RHEUMATISM diagnosis, RESEARCH, SEROPREVALENCE, COVID-19, IMMUNOGLOBULINS, SARS-CoV-2, FEVER, PEDIATRICS, IMMUNOSUPPRESSION, COUGH, RHEUMATISM, IMMUNOSUPPRESSIVE agents, POLYMERASE chain reaction, FATIGUE (Physiology) |
مصطلحات جغرافية: |
NEW York (State) |
مستخلص: |
Objectives Immunosuppressed paediatric patients with rheumatic disease (RD) may be at risk for severe or critical disease related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Data remain scarce on coronavirus disease 2019 (COVID-19) outcomes in paediatric RD patients. The aim of this study was to determine the seroprevalence of SARS-CoV-2 IgG and to describe COVID-19 outcomes in immunosuppressed paediatric RD patients. Methods Patients diagnosed with RD before age 18 years and treated with at least one immunosuppressive medication for at least 3 months were enrolled from a tertiary paediatric rheumatology practice in New York and also underwent routine SARS-CoV-2 IgG testing from May to November 2020. A total of 571 patients were screened and 262 were enrolled. SARS-CoV-2 IgG-positive subjects were assessed for symptoms of COVID-19 infection. SARS-CoV-2 PCR results were recorded where available. Demographic, diagnostic, medication and outcome data were collected. Results Of 262 subjects (186 female), 35 (13%) were SARS-CoV-2 IgG positive; 17 (49%) had symptoms suggestive of COVID-19. Of the 17 patients who had SARS-CoV-2 PCR testing, 11 (65%) were PCR positive, 7 of whom were IgG positive. Most SARS-CoV-2 IgG-positive subjects were not PCR tested. The most common symptoms in IgG- and/or PCR-positive subjects were fever, fatigue and cough. No SARS-CoV-2 IgG- or PCR-positive subject developed severe or critical COVID-19 or required hospitalization. Conclusions This is the first report of clinical outcomes of SARS-CoV-2 infection and seroprevalence of SARS-CoV-2 IgG in a large cohort of paediatric RD patients. Most SARS-CoV-2 IgG-positive subjects had no symptoms of COVID-19 infection. Symptomatic subjects all had mild COVID-19 symptoms, suggesting that the risk of severe or critical COVID-19 in immunosuppressed paediatric RD patients is minimal. [ABSTRACT FROM AUTHOR] |
|
Copyright of Rheumatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |