دورية أكاديمية
The Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies.
| العنوان: | The Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies. |
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| المؤلفون: | Xu, Jie, Li, Lin, Shi, Pengfei, Cui, Hongjuan, Yang, Liqun |
| المصدر: | International Journal of Molecular Sciences; Aug2022, Vol. 23 Issue 15, p8231-8231, 22p |
| مصطلحات موضوعية: | CARCINOGENESIS, DRUG resistance, MOUSE leukemia viruses, METASTASIS, NON-coding RNA |
| مستخلص: | B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved in regulating cell proliferation, differentiation and senescence, and maintaining the self-renewal of stem cells. Many studies in recent years have emphasized the role of Bmi-1 in the occurrence and development of tumors. In fact, Bmi-1 has multiple functions in cancer biology and is closely related to many classical molecules, including Akt, c-MYC, Pten, etc. This review summarizes the regulatory mechanisms of Bmi-1 in multiple pathways, and the interaction of Bmi-1 with noncoding RNAs. In particular, we focus on the pathological processes of Bmi-1 in cancer, and explore the clinical relevance of Bmi-1 in cancer biomarkers and prognosis, as well as its implications for chemoresistance and radioresistance. In conclusion, we summarize the role of Bmi-1 in tumor progression, reveal the pathophysiological process and molecular mechanism of Bmi-1 in tumors, and provide useful information for tumor diagnosis, treatment, and prognosis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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