دورية أكاديمية
Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity.
العنوان: | Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity. |
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المؤلفون: | Yuri Svirkin, Jaeweon Lee, Marx, Richard, Seongkyu Yoon, Landrau, Nelson, Kaisar, Md Abul, Bin Qin, Park, Jin H., Alam, Khondoker, Kozak, Darby, Yan Wang, Xiaoming Xu, Jiwen Zheng, Rivnay, Benjamin |
المصدر: | Asian Journal of Pharmaceutical Sciences; Jul2022, Vol. 17 Issue 4, p544-556, 13p |
مصطلحات موضوعية: | AMPHOTERICIN B, MYCOSES, ULTRAVIOLET-visible spectroscopy, POISONS, HEAT treatment, BILAYER lipid membranes, BLOOD platelet aggregation |
مستخلص: | Amphotericin B (AmB) is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections. Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer, which heat treatment (curing) modifies. Although toxicity was found related to aggregation status - loose aggregates significantly more toxic than tight aggregates - the precise mechanism linking aggregation and toxicity was not well understood. This study directly measured drug release rate from various AmB liposomal preparations made with modified curing protocols to evaluate correlations among drug aggregation state, drug release, and in vitro toxicity. UV-Vis spectroscopy of these products detected unique curing-induced changes in the UV spectral features: a ~25 nm blue-shift of the main absorption peak (λ |
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قاعدة البيانات: | Complementary Index |
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