التفاصيل البيبلوغرافية
| العنوان: |
Supramolecular Binding with Lectins: A New Route for Non-Covalent Functionalization of Polysaccharide Matrices. |
| المؤلفون: |
Montroni, Devis, Di Giosia, Matteo, Calvaresi, Matteo, Falini, Giuseppe |
| المصدر: |
Molecules; Sep2022, Vol. 27 Issue 17, p5633, 13p |
| مصطلحات موضوعية: |
POLYSACCHARIDES, CARBOHYDRATE-binding proteins, PLANT lectins, CHITIN, WHEAT germ, LECTINS, CARRIER proteins |
| مستخلص: |
The chemical functionalization of polysaccharides to obtain functional materials has been of great interest in the last decades. This traditional synthetic approach has drawbacks, such as changing the crystallinity of the material or altering its morphology or texture. These modifications are crucial when a biogenic matrix is exploited for its hierarchical structure. In this work, the use of lectins and carbohydrate-binding proteins as supramolecular linkers for polysaccharide functionalization is proposed. As proof of concept, a deproteinized squid pen, a hierarchically-organized β-chitin matrix, was functionalized using a dye (FITC) labeled lectin; the lectin used was the wheat germ agglutinin (WGA). It has been observed that the binding of this functionalized protein homogenously introduces a new property (fluorescence) into the β-chitin matrix without altering its crystallographic and hierarchical structure. The supramolecular functionalization of polysaccharides with protein/lectin molecules opens up new routes for the chemical modification of polysaccharides. This novel approach can be of interest in various scientific fields, overcoming the synthetic limits that have hitherto hindered the technological exploitation of polysaccharides-based materials. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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