دورية أكاديمية
Ring‐to‐Thread Chirality Transfer in [2]Rotaxanes for the Synthesis of Enantioenriched Lactams.
| العنوان: | Ring‐to‐Thread Chirality Transfer in [2]Rotaxanes for the Synthesis of Enantioenriched Lactams. |
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| المؤلفون: | Lopez‐Leonardo, Carmen, Saura‐Sanmartin, Adrian, Marin‐Luna, Marta, Alajarin, Mateo, Martinez‐Cuezva, Alberto, Berna, Jose |
| المصدر: | Angewandte Chemie; 9/26/2022, Vol. 134 Issue 39, p1-10, 10p |
| مصطلحات موضوعية: | ROTAXANES synthesis, CHIRALITY, CYCLIC compounds, LACTAMS, AMINO acids, RING formation (Chemistry) |
| مستخلص: | The synthesis of chiral mechanically interlocked molecules has attracted a lot of attention in the last few years, with applications in different fields, such as asymmetric catalysis or sensing. Herein we describe the synthesis of orientational mechanostereoisomers, which include a benzylic amide macrocycle with a stereogenic center, and nonsymmetric N‐(arylmethyl)fumaramides as the axis. The base‐promoted cyclization of the initial fumaramide thread allows enantioenriched value‐added compounds, such as lactams of different ring sizes and amino acids, to be obtained. The chiral information is effectively transmitted across the mechanical bond from the encircling ring to the interlocked lactam. High levels of enantioselectivity and full control of the regioselectivity of the final cyclic compounds are attained. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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