التفاصيل البيبلوغرافية
| العنوان: |
Characteristics of High and Low Frequency Conductivities in Patients with Alzheimer's Disease. |
| المؤلفون: |
Geon-Ho Jahng, Mun Bae Lee, Soonchan Park, Sue Min Jung, Hak Young Rhee, Chang-Woo Ryu, Oh In Kwon |
| المصدر: |
International Journal of Bioelectromagnetism; 2022 Supplement, Vol. 24, p162-165, 4p |
| مصطلحات موضوعية: |
ALZHEIMER'S patients, AMNESTIC mild cognitive impairment, OLDER patients, OLDER people |
| مستخلص: |
Previous studies reported increased concentrations of metallic ions and imbalanced Na+ and K+ ions in patients with Alzheimer's disease (AD) and the increased mobility of protons by microstructural disruptions in AD. The objective of this study was to evaluate characteristics of a high- and low-frequency conductivities in the participants with AD, amnestic mild cognitive impairment (MCI), and cognitively normal (CN) elderly people. This prospective study included 74 participants (23 AD patients, 27 amnestic MCI patients, and 24 CN elderly people) to explore the clinical application of high-frequncy conductivity (HFC). In addition, a independent prospective study included 34 participants (11 AD patients, 10 amnestic MCI patients, and 13 CN elderly people) to explore the clinical application of low-frequncy conductivity (LFC). The HFC value was higher in the AD group than in the CN and MCI groups. The high frequency conductivity (HFC) and low frequency conductivity of extra-neurite conductivity (EC) and intra-neurite conductivity (IC) were higher in the patients with AD than those with CN elderly people and patients with amnestic MCI. HFC values of the insula along with the GMV of the hippocampus can be used as an imaging biomarker to improve the differentiation of AD from CN. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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