دورية أكاديمية
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats.
| العنوان: | In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats. |
|---|---|
| المؤلفون: | Fazliogullari, Zeliha, Karabulut, Ahmet Kagan, Unver Dogan, Nadire, Uysal, Ismihan Ilknur, Acar, Hasan |
| المصدر: | Drug & Chemical Toxicology; Nov2022, Vol. 45 Issue 6, p2739-2747, 9p |
| مصطلحات موضوعية: | EMBRYOLOGY, PREDNISOLONE, POISONS, AZATHIOPRINE, MYCOPHENOLIC acid, GENETIC toxicology |
| مستخلص: | This study aimed to evaluate the effects of the glucocorticoid prednisolone, the mycophenolic acid prodrug, azathioprine, and the fungi fermentation end product, mycophenolate mofetile on the embryological development of rats. Nine day-old rat embryos were cultured in rat serum containing prednisolone at varying concentrations (5–30 µg/ml) for 48 h. The test groups were cultured separately in rat serum containing 0.3–10 µg/ml azathioprine and 1–10 µg/ml mycophenolate mofetile. Embryonic development parameter effects of both drugs in combination with prednisolone (20 µg/ml) were studied using morphological methods, with special attention given to the incidence of malformations. The genotoxic effects of agents evaluated with the TUNEL test revealed that prednisolone is not a cause of developmental toxicity. The maximum safe dose of prednisolone that could be used in combination with other immunosuppressive agents was determined to be 20 µg/ml. Azathioprine was found to be toxic and teratogenic for the rat embryos beginning at a dose of 1 µg/ml. Dose-dependent toxic and teratogenic effects of mycophenolate mofetile were detected at doses lower than normal clinical ones. [ABSTRACT FROM AUTHOR] |
| Copyright of Drug & Chemical Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
PDF full text from Publisher كن أول من يترك تعليقا!