التفاصيل البيبلوغرافية
| العنوان: |
Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential. |
| المؤلفون: |
Huldani, Huldani, Rashid, Ahmed Ibraheem, Turaev, Khikmatulla Negmatovich, Opulencia, Maria Jade Catalan, Abdelbasset, Walid Kamal, Bokov, Dmitry Olegovich, Mustafa, Yasser Fakri, Al-Gazally, Moaed E., Hammid, Ali Thaeer, Kadhim, Mustafa M., Ahmadi, Seyed Hossein |
| المصدر: |
Cell Communication & Signaling; 10/26/2022, Vol. 20 Issue 1, p1-14, 14p |
| مصطلحات موضوعية: |
CONCANAVALIN A, ANTINEOPLASTIC agents, CELL physiology, PLANT lectins, LECTINS, CANCER cells, CANCER treatment |
| مستخلص: |
Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular mechanism. It has been revealed that ConA can bind to several receptors on cancerous and normal cells and modulate the related signaling cascades. The most studied host receptor for ConA is MT1-MMP, responsible for most of the lectin's modulations, ranging from activating immune cells to killing tumor cells. In this study, in addition to studying the effect of ConA on signaling and immune cell function, we will focus on the most up-to-date advancements that unraveled the molecular mechanisms by which ConA can induce autophagy and apoptosis in various cancer cell types, where it has been found that P73 and JAK/STAT3 are the leading players. Moreover, we further discuss the main signaling molecules causing liver injury as the most significant side effect of the lectin injection. Altogether, these findings may shed light on the complex signaling pathways controlling the diverse responses created via ConA treatment, thereby modulating these complex networks to create more potent lectin-based cancer therapy. 9fPMniGPDqMZCFr2gmyU2E Video Abstract [ABSTRACT FROM AUTHOR] |
|
Copyright of Cell Communication & Signaling is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder