دورية أكاديمية
Comparitive Study Of Dexamethasone Vs Clonidine As An Adjuvant To Levobupivacaine In Transversus Abdominis Plane Block For Postoperative Pain In Patients Undergoing Total Abdominal Hystrectomy.
| العنوان: | Comparitive Study Of Dexamethasone Vs Clonidine As An Adjuvant To Levobupivacaine In Transversus Abdominis Plane Block For Postoperative Pain In Patients Undergoing Total Abdominal Hystrectomy. |
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| المؤلفون: | Varshney, Saurabh, Ahuja, Kanishak, Negi, Anoop Singh, Agrawal, Swati |
| المصدر: | Journal of Pharmaceutical Negative Results; 2022 Special Issue, Vol. 13, p98-109, 12p |
| مصطلحات موضوعية: | TRANSVERSUS abdominis muscle, POSTOPERATIVE pain, HYSTERO-oophorectomy, CLONIDINE, OXYGEN saturation, DEEP brain stimulation |
| مستخلص: | Introduction: Transversus abdominis plane (TAP) block is a regional anaesthetic technique in which a local anaesthetic agent is deposited in the TAP to block the sensory nerves supplying the anterior abdominal wall.1 TAP block has been used successfully for pain relief after Total Abdominal Hysterectomy (TAH), which in turn improved surgical outcome and decreases patient's morbidity. Aim: To compare the effect of 0.25% Levobupivacaine with 8mg Dexamethasaone (group LD) and 0.25% Levobupivacaine with 1.0 µg/kg bodyweight of Clonidine (group LC) on the duration of post-operative analgesia. Method: A prospective randomized double-blinded comparative study was conducted, involving hundred ASA I and II, adult patients posted for elective Total Abdominal Hysterectomy under general anaesthesia. The patients were randomly divided into two groups LD and LC, each comprising of fifty patients Group LD received 0.25% Levobupivacaine with 8mg Dexamethasaone and Group LC received 0.25% Levobupivacaine with 1.0 µg/kg bodyweight of Clonidine. USG guided TAP block was performed under all aseptic precautions, in the lumbar triangle of Petit bilaterally once the surgery has ended before extubation. The block effects in the two groups under study were compared in terms of postoperative Numeric Pain Rating scale (NPRS), duration of analgesia (time for first rescue demand) in the postoperative period upto 24 hours, number of demands for rescue analgesics, haemodynamic parameters like HR, SBP and DBP. Results: The demographic profile of patient in both the groups was similar with regard to age, sex, weight, BMI and ASA grade. NPRS was significanly lower in LD group at 1,2,4,6,8 and 12 hours postopertaively as compared to LC group. The time of first rescue analgesia was longer in LD group (626.40±40.93 minutes) versus LC-Group (403.40±31.63 minutes). The haemodynamaic parameters and arterial oxygen saturation of both the groups were comparable. Conclusion: Dexamethasone as adjuvant to 0.25% levobupivacaine (LD) reduces postoperative pain scores, prolongs the duration of analgesia and decreases demands for rescue analgesia in ultrasound guided transversus abdominis plane block in comparison to 0.25% levobupivacaine with clonidine (LC) without any clinically significant adverse effects. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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