التفاصيل البيبلوغرافية
| العنوان: |
Seroprevalence of SARS-CoV-2 antibodies in Italy in newborn dried blood spots. |
| المؤلفون: |
Galla, Luisa, Cosma, Chiara, Bertan, Michela, Altinier, Sara, Zaninotto, Martina, Basso, Daniela, Burlina, Alberto, Padoan, Andrea, Plebani, Mario |
| المصدر: |
Clinical Chemistry & Laboratory Medicine; 2023, Vol. 61 Issue 2, p311-315, 5p |
| مصطلحات موضوعية: |
SARS-CoV-2, IMMUNOGLOBULINS, NEWBORN infants, COVID-19 pandemic, SEROPREVALENCE |
| مصطلحات جغرافية: |
ITALY |
| مستخلص: |
Serosurveys can be used to monitor COVID-19 seroprevalence and conduct surveillance. Dried blood spot (DBS), used increasingly as a valuable sample to assay severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies (Ab), has several advantages, particularly in infants, due to the limited amount of blood required and its utility in testing a large number of samples in a limited time-frame. We evaluated SARS-CoV-2 IgG Ab prevalence in newborn DBS in the Trentino region of Italy, during the time period January 2020 – December 2021. Anti-SARS-CoV-2 IgG levels were determined in DBS by means of Anti-SARS-CoV-2 QuantiVac IgG ELISA assay (Euroimmun, Lubeck, Germany). Analyses included 2,400 DBS from newborns (54% M, 46% F), samples being collected 2–3 days after birth. The first DBS that tested positive for anti-SARS-CoV-2 IgG antibodies was found in March 2020 and, up to May 2020, only 4 positive results were detected overall. Starting from June 2020, the positivity thresholds increased according to the epidemiological waves of the COVID-19 pandemic in Italy, with a robust increment in the winters of 2020 and 2021. The percentage of positive DBS rose from 0 to 6% to 10–47%, in 2020 and 2021, respectively. This study demonstrates DBS is a suitable tool for both epidemiological purposes and surveillance in the SARS-CoV-2 pandemic, particularly in newborns and pregnant women, saving blood waste and sparing patients any discomfort. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
