دورية أكاديمية
Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997–2019.
| العنوان: | Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997–2019. |
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| المؤلفون: | Aizawa, Yuta, Kasamatsu, Takuhiro, Nagasawa, Koo, Watanabe, Kanako, Saitoh, Akihiko |
| المصدر: | Journal of Infectious Diseases; 1/15/2023, Vol. 227 Issue 2, p288-294, 7p |
| مصطلحات موضوعية: | MOLECULAR evolution, MOLECULAR epidemiology, VIRAL proteins, BAYESIAN analysis, NEWBORN infants |
| مصطلحات جغرافية: | JAPAN, NIIGATA-shi (Japan) |
| مستخلص: | Parechovirus-A3 (PeV-A3), first reported in 2004 in Japan, is an emerging pathogen that causes sepsis and meningoencephalitis in neonates and young infants. Although PeV-A3 has been identified worldwide, its epidemiological characteristics differ by region. To investigate the molecular evolution and epidemiology of PeV-A3, we performed genetic analyses of 131 PeV-A3 strains from the years 1997–2019 in Niigata, Japan. During 2016–2019, annual numbers remained steady, in contrast to the PeV-A3 epidemic interval of every 2–3 years that was observed in Japan from 2006. Bayesian evolutionary analysis of the complete viral protein 1 region revealed alternate dominant clusters during years of PeV-A3 epidemics. The branch including the oldest and first isolated PeV-A3 strains in Japan has been disrupted since 2001. The year of PeV-A3 emergence was estimated to be 1991. Continuous surveillance with genetic analyses of different regions will improve understanding of PeV-A3 epidemiology worldwide. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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