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Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging.

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العنوان: Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging.
المؤلفون: Grist, James T., Bøgh, Nikolaj, Hansen, Esben Søvsø, Schneider, Anna M., Healicon, Richard, Ball, Vicky, Miller, Jack J. J. J., Smart, Sean, Couch, Yvonne, Buchan, Alastair M., Tyler, Damian J., Laustsen, Christoffer
المصدر: Scientific Reports; 1/28/2023, Vol. 13 Issue 1, p1-12, 12p
مصطلحات موضوعية: METABOLIC clearance rate, MAGNETIC resonance imaging, RATS, CEREBRAL circulation
مستخلص: Hyperpolarized carbon-13 magnetic resonance imaging is a promising technique for in vivo metabolic interrogation of alterations between health and disease. This study introduces a formalism for quantifying the metabolic information in hyperpolarized imaging. This study investigated a novel perfusion formalism and metabolic clearance rate (MCR) model in pre-clinical stroke and in the healthy human brain. Simulations showed that the proposed model was robust to perturbations in T1, transmit B1, and kPL. A significant difference in ipsilateral vs contralateral pyruvate derived cerebral blood flow (CBF) was detected in rats (140 ± 2 vs 89 ± 6 mL/100 g/min, p < 0.01, respectively) and pigs (139 ± 12 vs 95 ± 5 mL/100 g/min, p = 0.04, respectively), along with an increase in fractional metabolism (26 ± 5 vs 4 ± 2%, p < 0.01, respectively) in the rodent brain. In addition, a significant increase in ipsilateral vs contralateral MCR (0.034 ± 0.007 vs 0.017 ± 0.02/s, p = 0.03, respectively) and a decrease in mean transit time (31 ± 8 vs 60 ± 2 s, p = 0.04, respectively) was observed in the porcine brain. In conclusion, MCR mapping is a simple and robust approach to the post-processing of hyperpolarized magnetic resonance imaging. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات: Complementary Index
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