دورية أكاديمية
Acute cytomegalovirus infection modulates the intestinal microbiota and targets intestinal epithelial cells.
| العنوان: | Acute cytomegalovirus infection modulates the intestinal microbiota and targets intestinal epithelial cells. |
|---|---|
| المؤلفون: | Le‐Trilling, Vu Thuy Khanh, Ebel, Jana‐Fabienne, Baier, Franziska, Wohlgemuth, Kerstin, Pfeifer, Kai Robin, Mookhoek, Aart, Krebs, Philippe, Determann, Madita, Katschinski, Benjamin, Adamczyk, Alexandra, Lange, Erik, Klopfleisch, Robert, Lange, Christian M., Sokolova, Viktoriya, Trilling, Mirko, Westendorf, Astrid M. |
| المصدر: | European Journal of Immunology; Feb2023, Vol. 53 Issue 2, p1-15, 15p |
| مصطلحات موضوعية: | GUT microbiome, CYTOMEGALOVIRUS diseases, EPITHELIAL cells, INTESTINAL infections, INFLAMMATORY bowel diseases |
| مستخلص: | Primary and recurrent cytomegalovirus (CMV) infections frequently cause CMV colitis in immunocompromised as well as inflammatory bowel disease (IBD) patients. Additionally, colitis occasionally occurs upon primary CMV infection in patients who are apparently immunocompetent. In both cases, the underlying pathophysiologic mechanisms are largely elusive ‐ in part due to the lack of adequate access to specimens. We employed the mouse cytomegalovirus (MCMV) model to assess the association between CMV and colitis. During acute primary MCMV infection of immunocompetent mice, the gut microbial composition was affected as manifested by an altered ratio of the Firmicutes to Bacteroidetes phyla. Interestingly, these microbial changes coincided with high‐titer MCMV replication in the colon, crypt hyperplasia, increased colonic pro‐inflammatory cytokine levels, and a transient increase in the expression of the antimicrobial protein Regenerating islet‐derived protein 3 gamma (Reg3γ). Further analyses revealed that murine and human intestinal epithelial cell lines, as well as primary intestinal crypt cells and organoids represent direct targets of CMV infection causing increased cell death. Accordingly, in vivo MCMV infection disrupted the intestinal epithelial barrier and increased apoptosis of intestinal epithelial cells. In summary, our data show that CMV transiently induces colitis in immunocompetent hosts by altering the intestinal homeostasis. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder كن أول من يترك تعليقا!