دورية أكاديمية
Bone morphogenetic protein 4 is involved in cadmium-associated bone damage.
العنوان: | Bone morphogenetic protein 4 is involved in cadmium-associated bone damage. |
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المؤلفون: | Wan, Yu, Mo, Li-jun, Wu, Lu, Li, Dong-li, Song, Jia, Hu, You-kun, Huang, Hai-bin, Wei, Qin-zhi, Wang, Da-peng, Qiu, Jian-min, Zhang, Zi-ji, Liu, Qi-zhan, Yang, Xing-fen |
المصدر: | Toxicological Sciences; Feb2023, Vol. 191 Issue 2, p201-211, 11p |
مصطلحات موضوعية: | BONE morphogenetic proteins, MESENCHYMAL stem cells, CADMIUM, PLURIPOTENT stem cells, ADIPOGENESIS |
مستخلص: | Cadmium (Cd) is a well-characterized bone toxic agent and can induce bone damage via inhibiting osteogenic differentiation. Bone morphogenetic protein (BMP)/SMAD signaling pathway can mediate osteogenic differentiation, but the association between Cd and BMP/SMAD signaling pathway is yet to be illuminated. To understand what elements of BMPs and SMADs are affected by Cd to influence osteogenic differentiation and if BMPs can be the biomarkers of which Cd-induced osteoporosis, human bone marrow mesenchymal stem cells (hBMSCs) were treated with cadmium chloride (CdCl |
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قاعدة البيانات: | Complementary Index |
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