التفاصيل البيبلوغرافية
| العنوان: |
Attenuation of Seizures, Cognitive Deficits, and Brain Histopathology by Phytochemicals of Imperata cylindrica (L.) P. Beauv (Poaceae) in Acute and Chronic Mutant Drosophila melanogaster Epilepsy Models. |
| المؤلفون: |
Ssempijja, Fred, Dare, Samuel Sunday, Bukenya, Edmund E. M., Kasozi, Keneth Iceland, Kenganzi, Ritah, Fernandez, Edgar Mario, Vicente-Crespo, Marta |
| المصدر: |
Journal of Evidence-Based Integrative Medicine; 3/3/2023, p1-26, 26p |
| مصطلحات موضوعية: |
COGNITION disorders, BRAIN, ANTICONVULSANTS, DRUG efficacy, MEDICINAL plants, FLAVONOIDS, POLYPHENOLS, IN vivo studies, ANALYSIS of variance, CONFIDENCE intervals, ANIMAL experimentation, ONE-way analysis of variance, FLIES, ANTIOXIDANTS, APOPTOSIS, PHYTOCHEMICALS, TOXICITY testing, DESCRIPTIVE statistics, PLANT extracts, SEIZURES (Medicine), CHROMONES, DATA analysis software |
| مستخلص: |
Imperata cylindrica is a globally distributed plant known for its antiepileptic attributes, but there is a scarcity of robust evidence for its efficacy. The study investigated neuroprotective attributes of Imperata cylindrica root extract on neuropathological features of epilepsy in a Drosophila melanogaster mutant model of epilepsy. It was conducted on 10-day-old (at the initiation of study) male post-eclosion bang-senseless paralytic Drosophila (parabss1) involved acute (1-3 h) and chronic (6-18 days) experiments; n = 50 flies per group (convulsions tests); n = 100 flies per group (learning/memory tests and histological examination). Administrations were done in 1 g standard fly food, per os. The mutant flies of study (parabss1) showed marked age-dependent progressive brain neurodegeneration and axonal degeneration, significant (P < 0.05) bang sensitivity and convulsions, and cognitive deficits due to up-regulation of the paralytic gene in our mutants. The neuropathological findings were significantly (P < 0.05) alleviated in dose and duration-dependent fashions to near normal/normal after acute and chronic treatment with extract similar to sodium valproate. Therefore, para is expressed in neurons of brain tissues in our mutant flies to bring about epilepsy phenotypes and behaviors of the current juvenile and old-adult mutant D. melanogaster models of epilepsy. The herb exerts neuroprotection by anticonvulsant and antiepileptogenic mechanisms in mutant D. melanogaster due to plant flavonoids, polyphenols, and chromones (1 and 2) which exert antioxidative and receptor or voltage-gated sodium ion channels' inhibitory properties, and thus causing reduced inflammation and apoptosis, increased tissue repair, and improved cell biology in the brain of mutant flies. The methanol root extract provides anticonvulsant and antiepileptogenic medicinal values which protect epileptic D. melanogaster. Therefore, the herb should be advanced for more experimental and clinical studies to confirm its efficacy in treating epilepsy. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Evidence-Based Integrative Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder