التفاصيل البيبلوغرافية
| العنوان: |
EXPLORING DIFFERENTIAL MUTATIONAL DISTRIBUTION BY TARGETED SEQUENCING IN A R‐CHOP TREATED COHORT OF DIFFUSE LARGE B‐CELL LYMPHOMA PATIENTS. |
| المؤلفون: |
Vimalathas, G., Lang, C. S., Hansen, M. H., Nyvold, C. G., Møller, M. B., Larsen, T. S. |
| المصدر: |
Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p654-655, 2p |
| مصطلحات موضوعية: |
DIFFUSE large B-cell lymphomas, ANTINEOPLASTIC combined chemotherapy protocols |
| مستخلص: |
Germinal center B-cell (GCB) DLBCL ( I n i = 60) displayed a differential somatic signature with enrichment of I EZH2 i , I TNFRSF14 i , I BCL2, ACTB, SOCS1, i and I FAS i mutations (Fisher's Exact, I p i < 10 SP -4 sp ), whereas mutations in I CDKN2A i , I PRDM1 i , I MYD88, i and I CD79B i were significantly enriched in non-GCB pts ( I p i < 10 SP -4 sp , I n i = 44). B Background: b Diffuse large B-cell lymphoma (DLBCL) harbors striking clinical and molecular heterogeneity, which continues to encumber risk stratification with a consequently high rate of refractory/relapsed patients (pts). EXPLORING DIFFERENTIAL MUTATIONAL DISTRIBUTION BY TARGETED SEQUENCING IN A R-CHOP TREATED COHORT OF DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
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