التفاصيل البيبلوغرافية
| العنوان: |
Streptothiazolidine B, a new cytotoxic alkaloid produced by Streptomyces violaceoruber. |
| المؤلفون: |
Wang, Tao, Kang, Da-Wei, Hu, Dong-Bao, Wang, Ji-Ai, Chen, Xiu, Cao, Yan-Ru, Wang, Ying, He, Jiang-Bo |
| المصدر: |
Journal of Asian Natural Products Research; Jun2023, Vol. 25 Issue 6, p595-602, 8p |
| مصطلحات موضوعية: |
CELL culture, ALKALOIDS, PHYTOCHEMICALS, CELL survival, CELL proliferation, RESEARCH funding, THIAZOLIDINEDIONES, CELL lines, CELL surface antigens, MOLECULAR structure, CHROMATOGRAPHIC analysis, IMMUNODIAGNOSIS |
| مستخلص: |
A new cytotoxic alkaloid, named streptothiazolidine B (1), together with three known compounds (2-4), were isolated from Streptomyces violaceoruber. The structure of the undescribed compound was established using 1D and 2D NMR, and HRESIMS. Streptothiazolidine B was isolated and identified as an amide alkaloid with a unique thiazolidine side chain and its absolute configuration was determined by a combination of NOESY experiment and ECD analysis. Streptothiazolidine B exhibited significant cytotoxic activities against two human tumor cell lines, Li-7 and A2780, with IC50 values of 7.8, and 9.1 μM. Meanwhile, compound 4 showed obvious cytotoxic activities against four human tumor cell lines, THP-1, HT29, Li-7 and A2780, with IC50 values ranging from 3.1 to 10.2 μM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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