التفاصيل البيبلوغرافية
| العنوان: |
The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. |
| المؤلفون: |
Delgado, Julio C., Leung, Jessica Y., Baena, Andres, Clavijo, Olga P., Vittinghoff, Eric, Buchbinder, Susan, Wolinsky, Steven, Addo, Marilynn, Walker, Bruce D., Yunis, Edmond J., Goldfeld, Anne E. |
| المصدر: |
Immunogenetics; Oct2003, Vol. 55 Issue 7, p497-501, 5p |
| مصطلحات موضوعية: |
HIV infections, AIDS, HISTOCOMPATIBILITY antigens, TUMOR necrosis factors, GENETIC polymorphisms |
| مستخلص: |
Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor (TNF) and the non-classical major histocompatibility (MHC) class I chain-related A (MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes have been identified. We thus analyzed TNF promoter and MICA variants in a well-characterized group of HIV-1 infected individuals with different abilities to control HIV-1 viremia. In our cohort, the -1030/-862-linked TNF promoter single-nucleotide polymorphisms (SNPs), but not MICA variants, are significantly associated with lack of control of HIV-1 viremia (P=0.03). This association is independent of those HLA-B35 alleles associated with HIV-1 disease progression with which the -862 TNF SNP has previously been independently associated. Thus, non-randomly associated genes near the TNF locus are likely involved in control of HIV-1 viremia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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