التفاصيل البيبلوغرافية
| العنوان: |
Cerebral Small Vessel Disease Burden and Futile Reperfusion after Endovascular Treatment for Patients with Acute Ischemic Stroke. |
| المؤلفون: |
Lee, Minwoo, Kim, Yerim, Oh, Mi Sun, Yu, Kyung-Ho, Lee, Byung-Chul, Kim, Chul-Ho, Mo, Hee Jung |
| المصدر: |
Cerebrovascular Diseases; Sep2023, Vol. 52 Issue 4, p427-434, 8p |
| مصطلحات موضوعية: |
CEREBRAL small vessel diseases, STROKE patients, ENDOVASCULAR surgery, CEREBRAL infarction, PESTE des petits ruminants, ISCHEMIC stroke, REPERFUSION |
| مصطلحات جغرافية: |
ALBERTA |
| مستخلص: |
Introduction: Cerebral small vessel disease (SVD) burden includes increased risk of poor functional outcomes after acute ischemic stroke (AIS). We aimed to investigate the impact of cerebral SVD on 3-month functional outcomes in patients with AIS who received endovascular treatment (EVT) and to determine whether SVD is associated with futile reperfusion (FR). Methods: Using a multicenter stroke registry, we analyzed consecutive patients with AIS with either intracranial and/or extracranial anterior circulation large artery occlusion, who were treated with EVT and achieved successful reperfusion (thrombolysis in cerebral infarction grade 2b–3). The cerebral SVD burden was evaluated using baseline brain magnetic resonance imaging using a modified Fazekas score (mFS). The main outcome variable was FR, defined as poor functional outcomes (modified Rankin scale 3–6) at 3 months after stroke, despite successful recanalization. Secondary outcomes included stroke progression/recurrence and any hemorrhagic transformation. Results: Among 10,890 patients with AIS, 577 (5.3%) received EVT within 12 h of onset, including 354 who met study eligibility criteria. FR was observed in 191 patients (53.5%) and was positively associated with SVD burden. After adjustment for covariates including age, sex, stroke etiology, initial stroke severity, collateral status, Alberta stroke program early CT score, initial serum glucose, systemic blood pressure, and vascular risk factors, mFS grade 3 was significantly associated with FR (odds ratio: 3.93, 95% confidence interval: 1.602–9.619; p = 0.003). Conclusions: We demonstrated that cerebral SVD assessed with baseline brain MRI is associated with the futility of successful recanalization after EVT and any hemorrhagic transformation but not with early stroke progression or recurrence. Nevertheless, our findings do not justify withholding EVT in otherwise eligible patients with AIS based on the presence of severe SVD. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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