التفاصيل البيبلوغرافية
| العنوان: |
Exploring Host-Specificity: Untangling the Relationship between Leishmania (Viannia) Species and Its Endosymbiont Leishmania RNA Virus 1. |
| المؤلفون: |
Santana, Mayara Cristhine de Oliveira, Chourabi, Khaled, Cantanhêde, Lilian Motta, Cupolillo, Elisa |
| المصدر: |
Microorganisms; Sep2023, Vol. 11 Issue 9, p2295, 13p |
| مصطلحات موضوعية: |
LEISHMANIA, RNA viruses, SPECIES, LEISHMANIASIS, DOUBLE-stranded RNA |
| مستخلص: |
A relevant aspect in the epidemiology of Tegumentary Leishmaniasis (TL) are the Leishmania parasites carrying a viral endosymbiont, Leishmania RNA Virus 1 (LRV1), a dsRNA virus. Leishmania parasites carrying LRV1 are prone to causing more severe TL symptoms, increasing the likelihood of unfavorable clinical outcomes. LRV1 has been observed in the cultured strains of five L. (Viannia) species, and host specificity was suggested when studying the LRV1 from L. braziliensis and L. guyanensis strains. The coevolution hypothesis of LRV1 and Leishmania was based on phylogenetic analyses, implying an association between LRV1 genotypes, Leishmania species, and their geographic origins. This study aimed to investigate LRV1 specificity relative to Leishmania (Viannia) species hosts by analyzing LRV1 from L. (Viannia) species. To this end, LRV1 was screened in L. (Viannia) species other than L. braziliensis or L. guyanensis, and it was detected in 11 out of 15 L. naiffi and two out of four L. shawi. Phylogenetic analyses based on partial LRV1 genomic sequencing supported the hypothesis of host specificity, as LRV1 clustered according to their respective Leishmania species' hosts. These findings underscore the importance of investigating Leishmania and LRV1 coevolution and its impact on Leishmania (Viannia) species dispersion and pathogenesis in the American Continent. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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