التفاصيل البيبلوغرافية
| العنوان: |
Optimization for synthesis of methyl-d3 cinnamate derivatives via room temperature Fischer esterification. |
| المؤلفون: |
Kurniawan, Yudhi Dwi, Ernawati, Teni, Lotulung, Puspa Dewi Narrij, Hanafi, Muhammad, Hashimoto, Makoto, Tachrim, Zetryana Puteri |
| المصدر: |
AIP Conference Proceedings; 2023, Vol. 2902 Issue 1, p1-7, 7p |
| مصطلحات موضوعية: |
CINNAMIC acid derivatives, CINNAMIC acid, ESTERIFICATION, ETHYL acetate, SULFURIC acid, DEUTERIUM, TEMPERATURE |
| مستخلص: |
Cinnamic acid ester derivatives are known to have important pharmacological properties. Replacement of hydrogen with deuterium at selective positions of potential drugs is known to allow less frequent and lower drug dosing. The synthesis of methyl-d3 cinnamate derivatives is introduced in this study. The room temperature Fischer esterification is conducted to present the methyl-d3 cinnamate derivatives in which deuterated methanol was used as deuterium source of the ester counterpart. Sulfuric acid is applied as a catalyst and ethyl acetate is also tried as a co-solvent for the utmost synthesis of cinnamic acid derivatives that resulted in a fair to excellent yield of methyl-d3 cinnamate derivatives. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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