التفاصيل البيبلوغرافية
| العنوان: |
MiR-708-5p exerts a potential therapeutic role in NSCLC male patients due to its involvement in transcription factor modulations. |
| المؤلفون: |
Raduly, Lajos, Bica, Cecilia, Farc, Ovidiu, Budisan, Liviuţa, Ciocan, Cristina, Haranguş, Antonia, Simon, Mărioara, Braicu, Cornelia, Berindan-Neagoe, Ioana |
| المصدر: |
Oncolog-Hematolog; 2023, Issue 64, p44-44, 1/3p |
| مصطلحات موضوعية: |
TRANSCRIPTION factors, HIPPO signaling pathway, NON-small-cell lung carcinoma |
| مستخلص: |
Non‐small cell lung cancer (NSCLC) comprises 85% of lung cancers. NSCLC has a high incidence and mortality. The present study aimed to investigate the role of miR-28-5p and miR-708-5p and to analyze the relationship between target coding genes and their signaling pathways. The two miRs were overexpressed in a patient cohort of 32 matched paired tumor and adjacent nontumoral tissue. All biological samples were collected from stage III and IV NSCLC patients. Due to the paralog structure of the two miRNAs, we conducted the study specifically on miR-708-5p, which showed a statistical significance between tumor tissue and adjacent nontumoral tissue. MiR-28-5p also revealed a significant difference, but at a lower level. We showed the critical roles of miR-28-5p and miR-708-5p in regulating ECM-receptor interaction, adherent’s junctions and Hippo signaling in the progression of NSCLC. Additional confirmation of the overexpression of miR-708-5p was done in the male TCGA patient cohort. The analysis using the Trans-Mir program revealed that the following transcriptional factors (TFs) may control miR-708: AR, ESR1, CREBBP, EOMES, EZH2, SOX2, TCF3/4, USF2; EZH2, JMJD1c, KDM2D, CXXC1, CXXC2, SFPQ, and MED1. These processes can be interrelated, particularly during the execution of the cell cycle. To analyze these connections, we performed a bioinformatics analysis of the correlation between TFs, based on genetic interactions, co-localization, physical interactions, co-expression and common pathways. We excluded predicted correlations and common protein domains. [ABSTRACT FROM AUTHOR] |
|
Copyright of Oncolog-Hematolog is the property of MEDICHUB MEDIA, S.R.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder