التفاصيل البيبلوغرافية
| العنوان: |
Unveiling the neuroinflammatory pathogenesis of persistent functional dyspepsia in H. pylori infection: Insights on MMP‐9 as a therapeutic target. |
| المؤلفون: |
Tseng, Yujen, Lin, Lingxi, Mo, Shaocong, Zhao, Suhan, Shen, Qiwei, Song, Huan, Cui, Haoshu, Zhang, Jun, Zheng, Wanwei, Luo, Zhongguang, Luo, Feifei, Liu, Jie |
| المصدر: |
Clinical & Translational Medicine; Nov2023, Vol. 13 Issue 11, p1-6, 6p |
| مصطلحات موضوعية: |
HELICOBACTER pylori infections, HELICOBACTER pylori, MATRIX metalloproteinases, INDIGESTION, NEURAL circuitry, PATIENT experience |
| مستخلص: |
This article discusses the neuroinflammatory pathogenesis of persistent functional dyspepsia in Helicobacter pylori (H. pylori) infection and highlights matrix metalloproteinase-9 (MMP-9) as a potential therapeutic target. The study found that even after successful eradication of H. pylori, a significant number of patients still experienced persistent dyspeptic symptoms. The researchers used various techniques to demonstrate disruption in the gastric neuronal network and a decrease in neuron density after H. pylori infection. They also identified MMP-9 as a key player in neuroinflammation and its correlation with macrophages and neuron apoptosis. These findings suggest that targeting neuroinflammation, specifically MMP-9, may be a promising approach for treating persistent dyspeptic symptoms in H. pylori infection. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
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