التفاصيل البيبلوغرافية
| العنوان: |
Group 1 and 3 innate lymphoid cells are increased in oral lichen planus and oral lichenoid lesions. |
| المؤلفون: |
Pan, Lei, Feng, Minghua, Chen, Junjun, Deng, Shu, Han, Xiaozhe, Wang, Yufeng, Tang, Guoyao |
| المصدر: |
Oral Diseases; Nov2023, Vol. 29 Issue 8, p3372-3380, 9p |
| مصطلحات موضوعية: |
FLOW cytometry, IMMUNOHISTOCHEMISTRY, ORAL lichen planus, DESCRIPTIVE statistics, RESEARCH funding, ORAL mucosa |
| مستخلص: |
Objectives: Innate lymphoid cells (ILCs) are vital innate immune cells cooperating with T cells. While their phenotypes and functions in oral mucosa kept unclear yet. In the present study, the relative proportions and distribution of different ILC subsets in oral mucosa of oral lichen planus (OLP), oral lichenoid lesions (OLL), and controls were compared. Subjects and Methods: Oral mucosal samples were collected from control (n = 29), OLP (n = 20), and OLL (n = 22) donors. ILCs subsets were characterized in single‐cell suspensions by flow cytometry. Immunohistochemistry was performed to locate the CD127+ cells in situ. Results: ILCs were present in healthy and increased infiltration in OLP/OLL (p = 0.0092, p = 0.0216). Infiltration of ILC1 increased in OLP/OLL mucosa (p = 0.0225, p = 0.0399), as did the infiltration of ILC3 increase in OLL mucosa (p = 0.0128). The ILC2/ILCs ratio was significantly reduced in OLP and OLL (p = 0.0124, p = 0.0346). CD127+ cells were mainly located closely at the basement membrane. Conclusions: The results of increased ILC1, decreased ILC2, and increased ILC3 suggested that changes of ILC distributions in oral mucosa may be relevant to persistent inflammation in local tissues, by promoting immune factors and weakening repair capacity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Oral Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder