التفاصيل البيبلوغرافية
| العنوان: |
Dapagliflozin improves erectile dysfunction in patients with type 2 diabetes mellitus: An open‐label, non‐randomized pilot study. |
| المؤلفون: |
Cannarella, Rossella, Condorelli, Rosita A., Leanza, Claudia, Garofalo, Vincenzo, Aversa, Antonio, Papa, Giuseppe, Calogero, Aldo E., La Vignera, Sandro |
| المصدر: |
Diabetic Medicine; Jan2024, Vol. 41 Issue 1, p1-11, 11p |
| مصطلحات موضوعية: |
DRUG efficacy, PILOT projects, IMPOTENCE, COMBINATION drug therapy, CLINICAL trials, TYPE 2 diabetes, SEVERITY of illness index, DAPAGLIFLOZIN, DOPPLER ultrasonography, QUESTIONNAIRES, DESCRIPTIVE statistics, DRUG synergism, TADALAFIL, PHARMACODYNAMICS |
| مستخلص: |
Introduction: The role of dapagliflozin on erectile dysfunction (ED), a condition widely affecting patients with type 2 diabetes mellitus (T2DM), has not yet been studied. Aim: The aim of the study was to evaluate the effects of dapagliflozin alone or in combination with tadalafil on ED in patients with T2DM. Methods: This was an open‐label, non‐randomized pilot study involving 30 Caucasian male patients with T2DM and severe ED. They were equally divided into three groups, assigned to treatment with tadalafil 5 mg/day (Group 1), tadalafil 5 mg/day plus dapagliflozin 10 mg/day (Group 2) and dapagliflozin 10 mg/day (Group 3) for 3 months. The presence and the severity of ED were evaluated at enrolment and after treatment, by the International Index of Erectile Function 5‐item (IIEF‐5) questionnaire and the dynamic penile echo colour Doppler ultrasound (PCDU) examination. Results: At the end of treatment, the three groups showed a significant improvement in IIEF‐5 score, by 294%, 375% and 197%, in Groups 1, 2 and 3, respectively. PCDU evaluation showed a significant increase in peak systolic velocity by 178.9%, 339% and 153%; acceleration time was significantly shortened in Group 2 (−26.2%) and was significantly lower than in Group 1 and 3 (−7.2% and −6.6%), while no significant difference was found in end‐diastolic velocity after treatment. The greatest rates of improvement were observed in Group 2 for all the end points. Conclusions: Dapagliflozin improves ED in patients with T2DM and enhances the efficacy of tadalafil. Further studies are needed to confirm our results explain the mechanism(s) by which dapagliflozin exerts its effects on ED. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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